I've asked a few people this question and it confuses most of them, so I'm gonna try to explain it as best I can
Everyone dies eventually. Some sooner than others. So, how do your characters die? It may be relevant to the story (I.e. Memphis getting shot at the end of Eastside, Leo succumbing to his cancer), something that happens outside the story but is still relevant to one or more stories (Colton's car crash, Markus drowning) or something completely irrelevant to any story.